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Updated: Jan 27, 2026
08:30
Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation
Published on: August 14, 2017
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[Von Willebrand disease in the elderly]
Nathalie Itzhar-Baïkian1,2, Agnès Veyradier1,2, Jean-Guillaume Dillinger3
1Service d'hématologie biologique, site constitutif du centre de référence maladie rare de la maladie de Willebrand, hôpital Lariboisière, AP-HP, Paris, France.
La Revue Du Praticien
|March 15, 2019
Summary
Von Willebrand disease (VWD) is a rare bleeding disorder. While VWD symptoms may decrease with age due to increased Von Willebrand factor levels, careful risk assessment is crucial before medical procedures or treatments.
Area of Science:
- Hematology
- Geriatrics
Background:
- Von Willebrand disease (VWD) is a rare inherited bleeding disorder with a prevalence of approximately 1/10,000 symptomatic individuals.
- VWD is characterized by a deficiency or dysfunction of Von Willebrand factor, leading to impaired platelet adhesion and aggregation.
Purpose of the Study:
- To explore the impact of aging on Von Willebrand disease presentation and management.
- To highlight the importance of multidisciplinary approaches and risk assessment in elderly VWD patients.
Main Methods:
- Literature review on VWD in the elderly.
- Analysis of factors influencing VWD severity with age.
- Discussion of management strategies for comorbidities and bleeding risks.
Main Results:
- Von Willebrand factor levels naturally increase with advanced age.
- This age-related increase may lead to a lower frequency and severity of cutaneous bleeding symptoms in elderly individuals with VWD.
- Management requires a case-by-case, multidisciplinary approach guided by expert recommendations.
Conclusions:
- Aging may mitigate some VWD symptoms, but comprehensive management remains essential.
- Systematic evaluation of bleeding risk is critical before invasive procedures or initiating anticoagulant, antiplatelet, or certain chemotherapy treatments in elderly VWD patients.
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