Another Score for the Pore: S. aureus Leukocidins Take a Shot on the Endothelium

Danielle N Alfano1, Juliane Bubeck Wardenburg1

  • 1Department of Pediatrics, Washington University School of Medicine, 660 S. Euclid Avenue, Box 8208, St. Louis, MO 63110, USA.

Cell Host & Microbe
|March 15, 2019
PubMed

Sepsis is a complex disease characterized by severe endothelial injury. In this issue of Cell Host & Microbe, Lubkin et al. (2019) reveal that an interaction between Staphylococcus aureus leukocidins and their cellular receptor DARC on endothelial cells leads to vascular injury, shedding light on pathogen-driven contributions to sepsis.

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