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Continuous subcutaneous insulin infusion: a long-term study.

A Lombardo, S Scavino, G Scornavacca

    Acta Diabetologica Latina
    |January 1, 1986
    PubMed
    Summary
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    Insulin requirement of simple and complex carbohydrate foods in type 1 (insulin-dependent) CSII-treated diabetic subjects, obtained by biostator. Correlation with glycaemic index.

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    Continuous Subcutaneous Insulin Infusion (CSII) using insulin pumps shows short-term benefits for diabetes management. However, long-term use presents challenges, including skin issues and potential complications.

    Area of Science:

    • Endocrinology
    • Metabolic Diseases
    • Medical Devices

    Background:

    • Insulin therapy is crucial for managing insulin-dependent diabetes.
    • Insulin pumps offer a method for continuous insulin delivery.

    Purpose of the Study:

    • To evaluate the long-term efficacy and safety of Continuous Subcutaneous Insulin Infusion (CSII).
    • To assess the validity of insulin pumps in sustained diabetes treatment.

    Main Methods:

    • A 3-year study involving 18 insulin-dependent subjects.
    • Administration of humanized insulin via insulin pumps in an outpatient setting.

    Main Results:

    • Significant improvement in metabolic parameters within the first month (p < 0.001).

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  • Metabolic control remained stable with minor fluctuations throughout the study.
  • Complications included ketosis from pump malfunctions and nodular skin lesions at infusion sites.
  • Four patients discontinued treatment due to skin lesions, which were more prevalent after one year of continuous use.

    • Conclusions:

    • CSII is a valid short-term treatment option for diabetes.
    • Long-term CSII use is associated with drawbacks, particularly skin complications related to treatment duration.