Related Experiment Video

Updated: Jan 27, 2026

In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

2.2K

Long-term biological variation of high-sensitivity cardiac troponin T using minimal important differences and

Tobias Täger1, Evangelos Giannitsis1, Kjeld Greve1

  • 1Zentrum für Innere Medizin, Klinik für Kardiologie, Angiologie und Pneumologie, Universitätsklinikum Heidelberg, Germany.

Clinical Biochemistry
|March 16, 2019
PubMed

Insights

Biological variation of high-sensitivity cardiac troponin T (hs-cTnT) in stable cardiovascular disease patients over 12 months depends on baseline levels. Minimal important difference (MID) shows low biovariability, aiding clinical interpretation of hs-cTnT changes.

Area of Science:

  • Cardiology
  • Clinical Chemistry
  • Biomarker Analysis

Background:

  • Cardiovascular disease (CVD) management relies on monitoring biomarkers like high-sensitivity cardiac troponin T (hs-cTnT).
  • Understanding the long-term biological variation of hs-cTnT is crucial for accurate interpretation in stable outpatients.

Purpose of the Study:

  • To evaluate the long-term biological variation of hs-cTnT in stable outpatients with CVD.
  • To determine reference change values (RCVs) and minimal important differences (MIDs) for hs-cTnT over a 12-month interval.

Main Methods:

  • hs-cTnT was measured at baseline and 12 months in 169 stable CVD outpatients.
  • Exclusion criteria were applied to 965 patients to ensure cohort stability.
  • Biological variation was assessed using RCVs and MIDs, analyzed across subgroups (sex, age, renal function).

Main Results:

  • The 12-month minimal important difference (MID) was 3.8 ng/L (44.2%), and the reference change value (RCV) was 5.1 ng/L (28.1%).
  • MID and RCV were dependent on baseline hs-cTnT concentrations, converging between 11-25 ng/L.
  • Similar patterns were observed across subgroups, indicating consistent biological variation.

Conclusions:

  • Long-term biological variation of hs-cTnT in stable CVD outpatients is influenced by baseline concentration.
  • Minimal important difference (MID) demonstrates low biovariability over 12 months, supporting its clinical utility.
  • Findings are consistent across key subgroups, enhancing the reliability of hs-cTnT interpretation.
Abstract

Keywords:
Biological variationCardiovascular diseaseHigh sensitivity troponin TOutpatients

More Related Videos

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

2.1K
Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training07:40

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training

Published on: October 10, 2019

7.7K

Related Concept Videos

Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
464
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
840
Variation: Normal Distribution, Range, and Standard Deviation02:32

Variation: Normal Distribution, Range, and Standard Deviation

In the field of psychology, there are several ways to organize measurements of a trait, feature, or characteristic (i.e., variables). Qualitative data, such as ethnicity, can be tabulated into a frequency count to provide information about the proportion, as well as the variety of groups in a sample or population. On the other hand, researchers can perform a wider set of calculations on quantitative data. The mean, mode, and median, for instance, are central tendency measures to identify a...
27.6K
Biological Effects of Radiation02:59

Biological Effects of Radiation

All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
17.8K
Standard Entropy Change for a Reaction03:00

Standard Entropy Change for a Reaction

Entropy is a state function, so the standard entropy change for a chemical reaction (ΔS°rxn) can be calculated from the difference in standard entropy between the products and the reactants.
24.2K
Biodiversity and Human Values01:24

Biodiversity and Human Values

Human civilization relies on biodiversity in many ways. Sudden changes in species biodiversity result in environmental changes that can modify weather patterns and therefore human civilizations.
17.0K