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Published on: December 23, 2016
Building a Cocrystal by Using Supramolecular Synthons for Pressure-Accelerated Heteromolecular Azide-Alkyne
Xiao Meng1, Changqing Chen2, Xinyuan Deng1
1Beijing National Laboratory for Molecular Sciences (BNLMS), Center for Soft Matter Science and Engineering, Key Lab of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry, Peking University, Beijing, 100871, P. R. China.
Abstract:
Facilitated by the supramolecular synthons of carboxylic acids and amides through cooperative hydrogen-bonding and arene-perfluoroarene interactions, the azide-alkyne cycloaddition reaction between two different molecules in a cocrystal was achieved. This reaction could be accelerated by pressure using a common hydraulic press equipment with excellent regioselectivity to yield 1,4-triazole products. The absence of decarboxylation side reactions in the products in the solid state demonstrated that this strategy can provide a green synthetic route for products not directly accessible by traditional syntheses in solution.
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