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T-bet+ memory B cells: Generation, function, and fate.

James J Knox1, Arpita Myles1, Michael P Cancro1

  • 1Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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|March 16, 2019
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Summary
This summary is machine-generated.

T-bet+ B cells are key immune players, aiding defense against pathogens but also risking autoimmunity. Understanding these cells offers therapeutic potential for immunity and autoimmune disease.

Keywords:
T-bet+ B cellshumoral autoimmunityintracellular pathogensmemory B cellsplasma cellstissue-resident memory B cells

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Area of Science:

  • Immunology
  • Cell Biology

Background:

  • B cells expressing the transcription factor T-bet (T-bet+ B cells) are involved in both protective and harmful immune responses.
  • These cells differentiate upon stimulation by Toll-like receptors and cytokines, producing IgG2a/c and mediating antibody-independent immunity, but can also generate autoantibodies.

Purpose of the Study:

  • To review the discovery and characteristics of T-bet+ B cells in mice and humans.
  • To discuss the origins, persistence, and in vivo fate of T-bet+ B cells.
  • To highlight T-bet+ B cells as a potential therapeutic target for enhancing humoral immunity and preventing autoimmunity.

Main Methods:

  • Literature review of existing research on T-bet+ B cells.
  • Analysis of data regarding differentiation, function, and characteristics in mice and humans.

Main Results:

  • T-bet+ B cells are a distinct subset originating from germinal centers.
  • They play a role in protective immunity against intracellular pathogens.
  • These cells are associated with the production of autoantibodies and autoimmunity.

Conclusions:

  • T-bet+ B cells represent a unique memory population.
  • Further research into T-bet+ B cells could lead to novel therapeutic strategies.
  • Targeting T-bet+ B cells may improve humoral immunity and combat autoimmune diseases.