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Updated: Jan 27, 2026

Engineering Antiviral Agents via Surface Plasmon Resonance
Published on: June 14, 2022
Noninvasive measurement of the refractive index of cell organelles using surface plasmon resonance microscopy
Abstract:
The health of a eukaryotic cell depends on the proper functioning of its cell organelles. Characterizing these nanometer- to micrometer-scaled specialized subunits without disturbing the cell is challenging but can also provide valuable insights regarding the state of a cell. We show that objective-based scanning surface plasmon resonance microscopy can be used to analyze the refractive index of cell organelles quantitatively in a noninvasive and label-free manner with a lateral resolution at the diffraction limit.
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