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Deep/mixed cerebral microbleeds are associated with cognitive dysfunction through thalamocortical connectivity
Yingzhe Wang1, Yanfeng Jiang2, Chen Suo3
1Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Neuroimage. Clinical
|March 16, 2019
Summary
Deep/mixed cerebral microbleeds (CMBs) are linked to cognitive dysfunction in older Chinese adults. This suggests thalamocortical connectivity disruption may be a key factor.
Area of Science:
- Neuroimaging
- Neurology
- Cognitive Science
Background:
- Cerebral microbleeds (CMBs) are associated with cognitive dysfunction.
- CMB pathology and clinical effects vary by location.
- Investigating CMBs' location-specific impact on cognition is crucial.
Purpose of the Study:
- To examine the association between CMBs at different brain locations and cognitive dysfunction.
- To explore potential underlying neurobiological pathways in a rural Han Chinese population.
Main Methods:
- Utilized baseline data from 562 community-dwelling adults (55-65 years) from the Taizhou Imaging Study.
- Performed multimodal brain MRI and neuropsychological tests (MMSE, MoCA) on 444 subjects.
- Employed multinomial logistic regression, Freesurfer, and tract-based spatial statistics for analysis.
Main Results:
- CMBs were present in 18.5% of participants.
- Deep/mixed CMBs significantly correlated with global cognitive dysfunction (OR 3.52).
- Lobar CMBs showed no significant association (OR 1.76).
- Deep/mixed CMBs were linked to reduced thalamic volume and white matter integrity (anterior thalamic radiations).
Conclusions:
- Deep/mixed CMBs are associated with cognitive dysfunction in this Chinese population.
- Disrupted thalamocortical connectivity may underlie this association.
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