Seno-suppressive molecules as new therapeutic perspectives in rheumatic diseases

Area of Science:

• Gerontology
• Cell Biology
• Rheumatology

Background:

• Cellular senescence, a non-proliferative state, is increasingly recognized as a key driver of age-related chronic diseases.
• This cellular syndrome creates a harmful microenvironment, promoting inflammation and tissue degradation, notably in conditions like osteoarthritis and osteoporosis.

Purpose of the Study:

• To review current knowledge on cellular senescence.
• To outline strategies for identifying senolytic agents.
• To discuss the translation of these therapies to rheumatic diseases.

Main Methods:

• Literature review of in vitro and animal model studies.
• Analysis of therapeutic strategies targeting cellular senescence.
• Examination of preclinical data for senolytic agents in rheumatic diseases.

Main Results:

• Cellular senescence is implicated in the pathogenesis of osteoarthritis and osteoporosis.
• Targeting senescent cells via senolytic agents has shown significant improvements in preclinical models.
• These interventions extend health span and ameliorate clinical signs of age-related diseases.

Conclusions:

• Cellular senescence is a critical therapeutic target for age-related chronic diseases.
• Senolytic agents hold promise for treating rheumatic conditions by clearing deleterious senescent cells.
• Further research and clinical translation are warranted to harness the potential of senotherapeutics.