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Published on: December 27, 2024
Egg source natural proteins LBL modified cellulose nanofibrous mats and their cellular compatibility
Dan Li1, Yanxiang Cheng2, Iqra Shahzadi1
1Hubei International Scientific and Technological Cooperation Base of Sustainable Resource and Energy, Hubei Key Laboratory of Biomass Resource Chemistry and Environmental Biotechnology, School of Resource and Environmental Science, Wuhan University, Wuhan, 430079, China.
Abstract:
Natural-based nanocomposites are competitive and promising materials for biomedical applications due to their biocompatibility. Herein, a novel natural-based composite was fabricated by alternately depositing lysozyme (LY) and albumin egg (AE) on electrospun cellulose nanofibrous mats via layer-by-layer self-assembly (LBL) technology. To indicate the successful deposition process and investigate the variations of the mats during LBL process, the surface morphology, physical property, chemical composition, wetting behavior and thermal stability were systematically studied. The results showed that the surface morphology and composition of the mats were significantly influenced by LBL process, which further resulted in the variation of wetting behavior. Besides, the mechanical properties were enhanced after LBL modification. In addition, the LBL structured nanofibrous mats exhibited antibacterial activity and excellent biocompatibility with L929 fibroblasts. In brief, LY and AE coated LBL structured cellulose nanofibrous mats, especially the 15 bilayers coated mats, have considerably potential applications in the biomedical field.
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