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Risk Factors for Complications in Children with Staphylococcus aureus Bacteremia

Rana F Hamdy1, Daniele Dona2, Marni B Jacobs3

  • 1Department of Pediatrics, Children's National Health System, Washington, DC.

The Journal of Pediatrics
|March 19, 2019
PubMed

Insights

Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia in children is linked to more complications and longer infection duration. Methicillin-sensitive S aureus (MSSA) bacteremia had fewer complications.

Area of Science:

  • Pediatric Infectious Diseases
  • Bacteriology
  • Clinical Microbiology

Background:

  • Staphylococcus aureus (S aureus) bacteremia is a significant cause of morbidity and mortality in children.
  • Understanding risk factors for complications is crucial for effective management.
  • Distinguishing outcomes between methicillin-sensitive S aureus (MSSA) and methicillin-resistant S aureus (MRSA) is important.

Purpose of the Study:

  • To identify risk factors for complications in pediatric S aureus bacteremia.
  • To compare clinical characteristics and outcomes between MSSA and MRSA bacteremia in children.
  • To determine factors associated with the duration of bacteremia.

Main Methods:

  • Retrospective cohort study of children (≤18 years) hospitalized with S aureus bacteremia.
  • Comparison of clinical data and outcomes between MSSA and MRSA groups.
  • Multivariate regression and Poisson regression analyses to identify risk factors for complications and bacteremia duration.

Main Results:

  • Out of 394 S aureus bacteremia episodes, 70.8% were MSSA and 29.2% were MRSA.
  • MRSA infections were associated with a higher likelihood of complications (aOR 3.31) and longer bacteremia duration.
  • Catheter-related infections were less likely to be associated with complications (aOR 0.40).

Conclusions:

  • Pediatric S aureus bacteremia with MRSA is associated with increased complications and prolonged bacteremia.
  • Risk factors for complications and extended bacteremia duration include MRSA, specific infection sites, race, and delayed source control.
  • These findings highlight the importance of early identification and management of MRSA in pediatric bacteremia.
Abstract

Keywords:
MRSAStaphylococcus aureusbacteremiachildren

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