Building a Program: Implications for Infrastructure, Nursing Education, and Training for CAR T-Cell Therapy

Area of Science:

• Oncology
• Cellular Therapy
• Healthcare Administration

Background:

• Chimeric antigen receptor (CAR) T-cell therapy program development faces complex regulatory demands and operational variations.
• The implementation infrastructure significantly impacts nursing education and required competencies for CAR T-cell therapy administration.

Purpose of the Study:

• To provide an overview of operational strategies for CAR T-cell therapy program development.
• To examine oncology nurse education considerations within CAR T-cell therapy programs.
• To compare differing institutional approaches to CAR T-cell therapy program development, implementation, and staff training.

Main Methods:

• Comparison of freestanding CAR T-cell therapy programs versus those integrated within specialty areas.
• Exploration of accreditation and financial considerations in program development.
• Presentation of distinct features of inpatient and ambulatory care settings for CAR T-cell therapy.

Main Results:

• CAR T-cell therapy is expanding, with an increasing number of centers offering approved treatments.
• Operational approaches and staff training strategies vary between institutions.
• Accreditation and financial factors influence program development.

Conclusions:

• Standardized workflow components are essential for optimal patient outcomes in CAR T-cell therapy.
• Comprehensive staff education is critical for successful CAR T-cell therapy implementation.
• Effective program development and implementation are key to managing the growing demand for CAR T-cell therapy.