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Predictive Immune Modeling of Solid Tumors
08:50

Predictive Immune Modeling of Solid Tumors

Published on: February 25, 2020

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Targeting Trop-2 in solid tumors: future prospects

Saif Zaman1, Hassan Jadid2, Aaron C Denson2

  • 1Morsani College of Medicine, University of South Florida, Tampa, FL, USA.

Oncotargets and Therapy
|March 19, 2019
PubMed

Insights

Trop-2 targeted therapies, including antibody-drug conjugates (ADCs), show promise across various cancers. Clinical trials demonstrate Trop-2 ADCs offer safety and benefit, even in difficult-to-treat tumors like triple-negative breast cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunotherapy

Background:

  • Trop-2 is a transmembrane glycoprotein overexpressed in many cancer types.
  • Its expression is higher on tumor cells than normal cells, making it a target for cancer therapy.
  • Trop-2 targeted therapeutics, including antibody-drug conjugates (ADCs), are emerging treatments.

Purpose of the Study:

  • To review clinical trials involving Trop-2 targeted therapies.
  • To summarize the safety and efficacy of Trop-2 based ADCs.
  • To highlight the potential of Trop-2 as a therapeutic target in oncology.

Main Methods:

  • Literature review of clinical trials involving Trop-2.
  • Analysis of data on Trop-2 targeted antibody-drug conjugates (ADCs).
  • Evaluation of safety and clinical benefit across various tumor types.

Main Results:

  • Trop-2 targeted ADCs have demonstrated safety and clinical benefit in early-phase trials.
  • Positive results observed in difficult-to-treat cancers such as triple-negative breast cancer, platinum-resistant urothelial cancer, and small-cell lung cancer.
  • Trop-2 expression is consistently upregulated across diverse cancer types.

Conclusions:

  • Trop-2 is a validated target for developing novel cancer therapeutics.
  • Trop-2 based ADCs represent a promising therapeutic strategy with demonstrated clinical activity.
  • Further clinical investigation of Trop-2 targeted agents is warranted across a spectrum of malignancies.
Keywords:
Trop-2antibody–drug conjugatesoncotargetstargeted therapytrophoblast antigen 2

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