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Updated: Jan 27, 2026

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Fragility Assessment of Bovine Cortical Bone Using Scratch Tests
Published on: November 30, 2017
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Long Bone Union Accurately Predicted by Cortical Bridging within 4 Months
Frank DiSilvio1, Sarah Foyil2, Brett Schiffman3
1Loyola University Stritch School of Medicine, Maywood, Illinois.
JB & JS Open Access
|March 19, 2019
Summary
Early detection of fracture healing is possible. The presence of any bridging callus within four months accurately predicts union or nonunion in tibial and femoral shaft fractures, simplifying prognostication.
Area of Science:
- Orthopaedic surgery
- Traumatology
- Radiographic assessment
Background:
- Previous studies indicated bridging callus within 4 months predicts tibial shaft fracture healing.
- A consensus on early prognostication for long bone nonunion is lacking.
- This study prospectively evaluates early callus formation for predicting union in tibial and femoral shaft fractures.
Purpose of the Study:
- To assess the accuracy and reliability of bridging callus presence within 4 months for predicting union in tibial and femoral shaft fractures.
- To compare the predictive value of any bridging callus versus bicortical or tricortical bridging.
- To establish a simple and reliable method for early fracture healing prognostication.
Main Methods:
- Prospective cohort study of 126 tibial and femoral shaft fractures treated with intramedullary nailing.
- Radiographs taken 3-4 months postoperatively were assessed by three orthopaedic traumatologists.
- Chi-square analysis and kappa statistics were used to evaluate accuracy and interobserver reliability for predicting union/nonunion based on callus formation.
Main Results:
- The overall nonunion rate was 4%.
- Any bridging callus within 4 months accurately predicted union (121/122) and absence predicted nonunion (4/4).
- Bicortical and tricortical bridging showed higher accuracy when present but were less reliable and risked overestimating nonunion when absent.
Conclusions:
- The presence of any bridging callus within 4 months is a simple, accurate, and reliable predictor of final healing outcomes for tibial and femoral shaft fractures.
- Standard radiographs are sufficient for this assessment.
- Relying on bridging of additional cortices leads to overestimation of nonunion rates and reduced reliability.
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