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Quantification of Proliferative and Dead Cells in Enteroids
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Enteroids for Nutritional Studies.

Yue-Bang Yin1,2, Hugo R de Jonge1,2, Xin Wu1

  • 1Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences; Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production; Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Changsha, Hunan, 410125, China.

Molecular Nutrition & Food Research
|March 19, 2019
PubMed
Summary
This summary is machine-generated.

Enteroids, derived from intestinal stem cells, offer a superior model for nutritional studies compared to traditional methods. These advanced models better reflect human physiology, improving research accuracy in nutrition and gut health.

Keywords:
enteroid modelsintestinal barriersintestinal stem cellslocation-specific functionsnutrient transport

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Area of Science:

  • Gastroenterology and Nutrition Science
  • Stem Cell Biology
  • Model Organism Development

Background:

  • Traditional cell lines and animal models used in nutritional studies often fail to accurately replicate human physiological responses.
  • This limitation hinders the development of effective nutritional interventions and the understanding of diet-gut interactions.
  • A need exists for more physiologically relevant models in nutritional research.

Purpose of the Study:

  • To review existing models for nutritional studies.
  • To highlight the potential of enteroids as a novel and improved model system for nutritional research.
  • To discuss the advantages of enteroids in mimicking in vivo intestinal functions.

Main Methods:

  • Enteroids are cultured from intestinal stem cells, encompassing various intestinal cell types.
  • These models are maintained in long-term culture without significant genetic or physiological alterations.
  • Enteroids have been utilized to investigate diverse aspects of intestinal function and nutrient interactions.

Main Results:

  • Enteroids recapitulate key features of the in vivo intestinal epithelium.
  • They support the study of diet and nutrient effects on intestinal growth, development, and function.
  • Enteroids enable research into ion and nutrient transport, barrier function, and site-specific intestinal activities.

Conclusions:

  • Enteroids represent a significant advancement over conventional models for nutritional studies.
  • Their ability to mimic human intestinal physiology makes them invaluable for investigating nutrient absorption and gut health.
  • Enteroids are a promising model system with substantial potential for future nutritional research.