Resting CMRO2 fluctuations show persistent network hyper-connectivity following exposure to sub-concussive collisions
Allen A Champagne1, Nicole S Coverdale1, Joseph Y Nashed1
1Centre for Neuroscience Studies, Room 260, Queen's University, Kingston, ON K7L 3N6, Canada.
Neuroimage. Clinical
|March 19, 2019
Summary
Sub-concussive head impacts in football players increased default-mode network connectivity. This change was independent of altered cerebral blood flow and reactivity, suggesting robust neural alterations after head impacts.
Area of Science:
- Neuroscience
- Sports Medicine
- Medical Imaging
Background:
- Repetitive head impacts in sports may affect brain connectivity, particularly the default-mode network (DMN).
- Previous research has not fully accounted for how changes in resting cerebral blood flow (CBF0) and cerebrovascular reactivity (CVR) might influence connectivity after sub-concussive impacts.
Purpose of the Study:
- To investigate the relationship between neural and vascular factors in functional connectivity (FC) changes following sub-concussive impacts in collegiate football players.
- To examine the longitudinal effects of a football season on DMN connectivity, CBF0, and CVR.
Main Methods:
- Longitudinal study of 23 collegiate football players using calibrated resting-state MRI and helmet accelerometers.
- Analysis of functional connectivity (FC) using blood oxygen level dependent (BOLD) and cerebral metabolic rate of oxygen consumption (CMRO2) mapping.
- Assessment of resting cerebral blood flow (CBF0) and cerebrovascular reactivity (CVR) at multiple time points during and after the season.
Main Results:
- Cerebral blood flow (CBF0) decreased one month post-season, while cerebrovascular reactivity (CVR) was impaired mid-season and post-season compared to baseline.
- Default-mode network (DMN) connectivity increased throughout the season, irrespective of changes in CBF0 or CVR.
- No significant correlation was found between impact kinematics and DMN connectivity alterations.
Conclusions:
- Alterations in functional connectivity (FC) following sub-concussive impacts appear robust and independent of concurrent hemodynamic changes.
- Neurophysiological markers may exhibit different susceptibility timelines to head impacts compared to vascular markers.
- Findings support further research into the neural and vascular mechanisms underlying increased network connectivity after repeated head impacts to improve management strategies.
Keywords:
Calibrated resting-stateCerebrovascular physiologyFunctional connectivityHelmet accelerometersSub-concussive collisionsMore Related Videos
05:48Autonomic Function Following Concussion in Youth Athletes: An Exploration of Heart Rate Variability Using 24-hour Recording Methodology
Published on: September 21, 2018
10.5K
12:09Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
Published on: August 5, 2014
18.5K
Related Concept Videos
01:04Types Of Collisions - I
9.5K
When two objects come in direct contact with each other, it is called a collision. During a collision, two or more objects exert forces on each other in a relatively short amount of time. A collision can be categorized as either an elastic or inelastic collision. If two or more objects approach each other, collide and then bounce off, moving away from each other with the same relative speed at which they approached each other, the total kinetic energy of the system is said to be conserved. This...
9.5K
01:19Types of Collisions - II
9.9K
When two or more objects collide with each other, they can stick together to form one single composite object (after collision). The total mass of the object after the collision is the sum of the masses of the original objects, and it moves with a velocity dictated by the conservation of momentum. Although the system's total momentum remains constant, the kinetic energy decreases, and thus such a collision is an inelastic collision. Most of the collisions between objects in daily life are...
9.9K
01:21The Resting Membrane Potential
142.1K
Overview
142.1K
01:24Resting Membrane Potential
21.6K
The relative difference in electrical charge, or voltage, between the inside and the outside of a cell membrane, is called the membrane potential. It is generated by differences in permeability of the membrane to various ions and the concentrations of these ions across the membrane.
The Inside of a Neuron is More Negative
The membrane potential of a cell can be measured by inserting a microelectrode into a cell and comparing the charge to a reference electrode in the extracellular fluid. The...
The Inside of a Neuron is More Negative
The membrane potential of a cell can be measured by inserting a microelectrode into a cell and comparing the charge to a reference electrode in the extracellular fluid. The...
21.6K
02:43Basic Postulates of Kinetic Molecular Theory: Particle Size, Energy, and Collision
37.6K
The ideal-gas equation, which is empirical, describes the behavior of gases by establishing relationships between their macroscopic properties. For example, Charles’ law states that volume and temperature are directly related. Gases, therefore, expand when heated at constant pressure. Although gas laws explain how the macroscopic properties change relative to one another, it does not explain the rationale behind it.
37.6K
02:26Protein Networks
4.5K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.5K