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Updated: Jan 27, 2026
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Studying Interactions between Myeloid Cells and CAR T Cells In Vitro and In Vivo
Published on: July 25, 2025
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Studying interactions between dendritic cells and T cells in vivo
Aleksey Chudnovskiy1, Giulia Pasqual1, Gabriel D Victora1
1Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA.
Current Opinion in Immunology
|March 19, 2019
Summary
Dendritic cells (DCs) initiate T cell responses by presenting antigens. Advanced imaging techniques now allow in-depth study of DC-T cell interactions, enhancing our understanding of adaptive immunity.
Area of Science:
- Immunology
- Cell Biology
Background:
- Antigen presentation by dendritic cells (DCs) is crucial for initiating T cell responses.
- Dendritic cells (DCs) are professional antigen-presenting cells (APCs) vital for priming naive CD4+ and CD8+ T cells.
- DC-T cell interactions involve signal exchange that dictates the immune response's magnitude and quality.
Purpose of the Study:
- To survey the evolution of understanding T cell activation by DCs.
- To highlight the impact of new technologies on studying DC-T cell interactions in vivo.
Main Methods:
- Intravital multiphoton microscopy.
- Emerging in vivo imaging technologies.
Main Results:
- New technologies provide unprecedented insights into DC dynamics and distribution.
- The study reviews advancements in visualizing DC-T cell interactions in real-time.
Conclusions:
- Our comprehension of T cell activation by DCs has significantly advanced.
- In vivo studies using advanced microscopy are key to understanding adaptive immunity dynamics.
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