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Updated: Jan 27, 2026

An Immature Murine Model of Reversible Unilateral Ureteral Obstruction
Published on: April 4, 2025
Small bowel obstruction in a virgin abdomen.
Veljko Strajina1, Brian D Kim1, Martin D Zielinski1
1Department of Surgery, Mayo Clinic, Rochester, MN, USA.
Small bowel obstruction (SBO) in patients without prior abdominal surgery often has benign causes. Careful imaging review is crucial to detect subtle signs of malignancy, and non-operative management requires close follow-up.
Area of Science:
- Gastroenterology
- Surgical Oncology
- Abdominal Imaging
Background:
- Surgical exploration is often considered mandatory for small bowel obstruction (SBO) in patients with a virgin abdomen.
- Determining the etiology of SBO in this population is critical for appropriate management.
Purpose of the Study:
- To investigate the causes of small bowel obstruction (SBO) in patients who have not undergone previous abdominal surgery.
- To evaluate the diagnostic yield and outcomes of surgical exploration versus non-operative management in this patient group.
Main Methods:
- Retrospective review of 60 patients with SBO and a virgin abdomen treated at Mayo Clinic (2006-2016).
- Analysis of follow-up data, operative findings, and pathological results to determine SBO etiology.
- Correlation of clinical factors (leukocytosis, weight loss) with exploration outcomes.
Main Results:
- Of 60 patients, 50 (83%) underwent exploration, with 29 (58%) having therapeutic findings.
- Malignancy was diagnosed in 8 patients (13%), including colon cancer, small bowel neuroendocrine tumors, and lymphoma.
- Leukocytosis and absence of recent weight loss were associated with negative explorations.
Conclusions:
- Small bowel obstruction in patients with a virgin abdomen frequently stems from benign etiologies.
- Thorough review of imaging for subtle malignancy signs is essential.
- Non-operative management necessitates close follow-up, including history and colonoscopy.
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