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This study introduces a novel ultrasound and microfluidics technique for rapid, label-free cell sizing and counting. The method accurately measures cell dimensions, offering potential for advanced cellular characterization.

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Area of Science:

  • Biophysics
  • Microfluidics
  • Acoustics

Background:

  • Accurate cell sizing and counting are crucial for biological research and diagnostics.
  • Existing methods may require cell labeling or lack high-throughput capabilities.

Purpose of the Study:

  • To develop and validate a novel, high-throughput, label-free technique for rapid cell sizing and counting.
  • To integrate ultrasound and microfluidics for precise cellular dimension determination.

Main Methods:

  • Utilized 3D hydrodynamic flow focusing to stream cells in single file through a 375 MHz ultrasound beam.
  • Acquired ultrasound scattering events and analyzed spectral features of backscattered waves.
  • Determined cell sizes by comparing spectral features with theoretical models.

Main Results:

  • Successfully sized acute myeloid leukemia cells (mean 10.0 ± 1.7 μm) and HT29 colorectal cancer cells (mean 15.0 ± 2.3 μm).
  • Achieved high-throughput measurements (2,390 and 1,955 cells, respectively).
  • Results showed excellent agreement with Coulter Counter measurements.

Conclusions:

  • The combined ultrasound and microfluidics technique provides accurate, label-free cell sizing and counting.
  • This method holds significant potential for multi-parameter cellular characterization beyond size.