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Updated: Jan 27, 2026

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Old cogs, new tricks: the evolution of gene expression in a chromatin context

Paul B Talbert1, Michael P Meers1, Steven Henikoff2

  • 1Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

Nature Reviews. Genetics
|March 20, 2019
PubMed
Summary

Eukaryotic gene regulation involves nucleosomes, inherited from prokaryotes. Chromatin proteins evolved from DNA barriers to complex roles in development and differentiation.

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