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[LHON-Treatment option despite poor initial visual acuity?]

A Rickmann1, L Wocker2, L-J Damm2

  • 1Augenklinik Sulzbach, Knappschaft Krankenhaus Saar, An der Klinik 10, 66280, Sulzbach/Saar, Deutschland. arickmann@gmail.com.

Der Ophthalmologe : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft
|March 20, 2019
PubMed
Summary
This summary is machine-generated.

Leber's hereditary optic neuropathy, a rare mitochondrial disease, requires consideration in diagnostics. Early treatment can improve visual acuity, even in severe cases.

Keywords:
IdebenoneLeber’s hereditary optic neuropathyNervus opticusRaxonemitochondrial disease

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Area of Science:

  • Ophthalmology
  • Genetics
  • Neurology

Background:

  • Leber's hereditary optic neuropathy (LHON) is a rare, maternally inherited mitochondrial disease.
  • It primarily affects the optic nerve, leading to vision loss.
  • Accurate diagnosis and timely intervention are crucial for managing this condition.

Observation:

  • A case of Leber's hereditary optic neuropathy is presented.
  • The patient presented with very poor initial visual acuity.
  • Treatment was initiated late in the course of the disease.

Findings:

  • Despite late treatment initiation and severe initial vision impairment, the patient achieved clinically relevant visual acuity improvement.
  • This case highlights the potential for visual recovery in LHON.

Implications:

  • This case underscores the importance of including LHON in the differential diagnosis of optic neuropathies.
  • Current treatment strategies may offer benefits even when started late.
  • Further research into optimizing LHON treatment is warranted.