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Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies
Published on: August 11, 2023
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Oral Epithelial Dysplasia and Premalignancy.
Sook-Bin Woo1,2,3
1Harvard School of Dental Medicine, Boston, MA, USA. swoo@partners.org.
Head and Neck Pathology
|March 20, 2019
Summary
Oral potentially malignant disorders like leukoplakia and erythroplakia often show oral epithelial dysplasia (OED) on initial biopsy. Early hyperkeratosis without OED may precede dysplasia and oral cancer development.
Area of Science:
- Oral pathology
- Oral potentially malignant disorders
- Oral epithelial dysplasia
Background:
- Leukoplakia and erythroplakia are oral potentially malignant disorders.
- Oral epithelial dysplasia (OED) is frequently found in these lesions upon initial biopsy.
- Submucous fibrosis lesions develop OED over time.
Purpose of the Study:
- To discuss architectural features of OED.
- To differentiate OED from reactive lesions like traumatic/frictional keratoses.
- To highlight the progression from hyperkeratosis to OED and squamous cell carcinoma.
Main Methods:
- Histopathological examination of oral lesions.
- Description of key architectural features of OED.
- Differential diagnosis of leukoplakia and related conditions.
Main Results:
- Traumatic/frictional keratoses can be misdiagnosed as leukoplakia.
- Verrucous and papillary architecture, bulky proliferation, and atrophy are notable OED features.
- Hyperkeratosis without OED may precede dysplasia and squamous cell carcinoma.
Conclusions:
- Early hyperkeratosis without OED can be a precursor to dysplasia.
- Distinguishing OED from reactive keratoses is crucial for accurate diagnosis and management.
- Lymphocytic infiltration at the interface in leukoplakia with OED should not be confused with oral lichen planus.
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