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Automated Robotic Liquid Handling Assembly of Modular DNA Devices
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Automated Glycan Assembly: A Perspective.

Mónica Guberman1,2, Peter H Seeberger1

  • 1Department of Biomolecular Systems , Max Planck Institute of Colloids and Interfaces , Am Mühlenberg 1 , 14476 Potsdam , Germany.

Journal of the American Chemical Society
|March 20, 2019
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Summary

Automated Glycan Assembly (AGA) simplifies the creation of pure synthetic glycans, advancing glycosciences for diagnostics and therapeutics. This technology provides essential molecular tools for glycobiology research across various species.

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Area of Science:

  • Carbohydrate Chemistry
  • Glycobiology
  • Synthetic Chemistry

Background:

  • Complex carbohydrate structures pose challenges in obtaining pure glycans, hindering glycoscience research.
  • Automated Glycan Assembly (AGA) has emerged as a key technology to overcome these limitations.

Purpose of the Study:

  • To provide an overview of the current state of Automated Glycan Assembly (AGA).
  • To highlight the applications of synthetic glycans produced by AGA in various research fields.
  • To identify areas for future improvement in AGA technology.

Main Methods:

  • Review of recent advances and applications of Automated Glycan Assembly (AGA).
  • Discussion of the general approach for synthesizing complex glycans from diverse biological sources.
  • Analysis of the technological aspects and limitations of current AGA methods.

Main Results:

  • AGA enables the production of pure synthetic glycans from mammalian, bacterial, fungal, and plant sources.
  • Synthetic glycans serve as crucial molecular tools for diagnostics, vaccine development, and enzyme characterization.
  • Recent advancements in AGA facilitate the creation of novel carbohydrate-based materials.

Conclusions:

  • Automated Glycan Assembly (AGA) is a powerful technology for advancing glycobiology research.
  • Further improvements in AGA are needed to fully realize its potential in producing diverse and complex glycans.
  • AGA-synthesized glycans are vital for structure-function relationship studies and the development of new therapeutics and diagnostics.