Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is Evolutionary History?02:35

What is Evolutionary History?

43.2K
Scientists record evolutionary history by analyzing fossil, morphological, and genetic data. The fossil record documents the history of life on Earth and provides evidence for evolution. However, both fossil and living organisms offer evidence that outlines Earth’s evolutionary history.
43.2K
Evolutionary Psychology01:20

Evolutionary Psychology

989
Evolutionary psychology explores the origins of human behavior and mental processes by framing them within the context of natural selection, a theory famously propounded by Charles Darwin. This field asserts that many behaviors common across human societies — ranging from instinctive fear reactions to complex social interactions — arose as evolutionary adaptations. These adaptations enhanced the survival and reproductive success of our ancestors, thereby becoming embedded in the...
989
Criticisms of the Evolutionary Perspective01:23

Criticisms of the Evolutionary Perspective

361
In a study where individuals posing as strangers offered compliments and proposed casual sex to students, the responses differed significantly based on gender. Not a single woman accepted the proposal, while 70% of the men agreed. This outcome provides a useful scenario to explore through the lens of evolutionary psychology and social learning theory, highlighting the diverse perspectives on human sexual behaviors.
Evolutionary psychology provides one explanation for these findings, suggesting...
361
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

7.0K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
7.0K
C4 Pathway and CAM01:27

C4 Pathway and CAM

49.1K
Most plants use the C3 pathway for carbon fixation. However, some plants, such as sugar cane, corn, and cacti that grow in hot conditions, use alternative pathways to fix carbon and conserve energy loss due to photorespiration. Photorespiration is the process that occurs when the oxygen concentration is high. Under such conditions, the rubisco enzyme in the Calvin cycle binds O2 instead of CO2, which halts photosynthesis and consumes energy.
C4 Pathway
The C4 pathway is used by plants such as...
49.1K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

6.4K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
6.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Atlas of human gut-associated lymphoid tissue reveals immunomodulatory interactions of B cells.

Science immunology·2026
Same author

Murine osteosarcoma recapitulates the driver landscape and genomic complexity of osteosarcoma evolution in humans.

bioRxiv : the preprint server for biology·2026
Same author

An international framework for clinical translation of molecular classifiers in osteosarcoma.

NPJ precision oncology·2026
Same author

Single-cell transcriptomics identifies regulatory T cell heterogeneity in gestational diabetes mellitus.

Communications medicine·2026
Same author

Reliable classification of polyps based on artificial intelligence: a development and validation study.

EClinicalMedicine·2026
Same author

Validation of Digital Cytology for Primary Diagnosis Across a Range of Specimen Types.

Cytopathology : official journal of the British Society for Clinical Cytology·2026
Same journal

Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis.

Cancer cell·2026
Same journal

Vascular RhoJ Is an Effective and Selective Target for Tumor Angiogenesis and Vascular Disruption.

Cancer cell·2026
Same journal

Intratumoral B cells under stress.

Cancer cell·2026
Same journal

Chronic stress unleashes an intratumor phage-fibroblast-B cell circuit to promote tumor growth.

Cancer cell·2026
Same journal

Molecular phenotypes and spatial archetypes: A new framework for cancer-associated fibroblasts.

Cancer cell·2026
Same journal

OpenIO: An open framework for AI-native immunotherapy.

Cancer cell·2026
See all related articles

Related Experiment Video

Updated: Jan 27, 2026

The In ovo CAM-assay as a Xenograft Model for Sarcoma
12:44

The In ovo CAM-assay as a Xenograft Model for Sarcoma

Published on: July 17, 2013

26.3K

Undifferentiated Sarcomas Develop through Distinct Evolutionary Pathways.

Christopher D Steele1, Maxime Tarabichi2, Dahmane Oukrif1

  • 1Research Department of Pathology, Cancer Institute, University College London, London WC1E 6BT, UK.

Cancer Cell
|March 20, 2019
PubMed
Summary
This summary is machine-generated.

Undifferentiated sarcomas (USARCs) show high structural complexity due to whole genome duplication. Mathematical models reveal diverse evolutionary paths and identify immune infiltration linked to better prognosis in some rare soft tissue cancers.

Keywords:
cancer evolutioncopy-number signaturesgenomicsimmuno-oncologymutational signaturessarcomatumor mutational burden

More Related Videos

Isolation of Distinct Cell Populations from the Developing Cerebellum by Microdissection
08:02

Isolation of Distinct Cell Populations from the Developing Cerebellum by Microdissection

Published on: September 21, 2014

10.0K
Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
07:18

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

7.4K

Related Experiment Videos

Last Updated: Jan 27, 2026

The In ovo CAM-assay as a Xenograft Model for Sarcoma
12:44

The In ovo CAM-assay as a Xenograft Model for Sarcoma

Published on: July 17, 2013

26.3K
Isolation of Distinct Cell Populations from the Developing Cerebellum by Microdissection
08:02

Isolation of Distinct Cell Populations from the Developing Cerebellum by Microdissection

Published on: September 21, 2014

10.0K
Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
07:18

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

7.4K

Area of Science:

  • Oncology
  • Genomics
  • Cancer Biology

Background:

  • Undifferentiated sarcomas (USARCs) are rare, aggressive adult soft tissue cancers.
  • USARCs are characterized by a high burden of structural genomic aberrations.

Purpose of the Study:

  • To elucidate the molecular underpinnings of structural complexity in USARCs.
  • To integrate multi-omic data for a comprehensive understanding of USARC tumorigenesis.

Main Methods:

  • DNA sequencing, ploidy analysis, gene expression, and methylation profiling were integrated.
  • Mathematical deconvolution strategies and mutational timing models were employed.
  • Analysis focused on identifying whole genome duplication and evolutionary pathways.

Main Results:

  • Whole genome duplication was identified as a frequent driver in USARC development.
  • Distinct tumor evolutionary trajectories were inferred using computational models.
  • A subset of 15% of tumors showed increased mutational burden associated with immune infiltration and favorable prognosis.

Conclusions:

  • Whole genome duplication is a key factor contributing to the genomic complexity of undifferentiated sarcomas.
  • Understanding USARC evolutionary pathways can inform therapeutic strategies.
  • Immune infiltration signatures may indicate a subset of USARCs with better clinical outcomes.