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Related Concept Videos

Drug Delivery: Overview01:16

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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Drug control governance involves the oversight and regulation of pharmaceuticals to ensure their safety and efficacy while preventing illegal drug use and trafficking. Regulatory bodies, including the US Food and Drug Administration (FDA) and the European Union's European Medicines Agency (EMA), play a central role in this process. These agencies evaluate the safety and efficacy of drugs before they can be marketed. They fund clinical trials and assess the benefits and risks associated with...
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Implantation of Electrospun Vascular Grafts with Optimized Structure in a Rat Model
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Sintered electrospun polycaprolactone for controlled model drug delivery.

Francisco J Chaparro1, Kayla F Presley1, Marco A Coutinho da Silva2

  • 1Department of Materials Science and Engineering, The Ohio State University, 2041 College Road, Columbus, OH 43210, USA.

Materials Science & Engineering. C, Materials for Biological Applications
|March 21, 2019
PubMed
Summary

Sintering electrospun polycaprolactone fibers created capsules for long-term drug delivery. Higher sintering temperatures reduced porosity, controlling drug release over extended periods, with some capsules releasing drugs for over 12 days.

Keywords:
ContraceptiveElutionEquineMethadonePharmaceuticalSustained release

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Materials Engineering

Background:

  • Electrospinning is a versatile technique for creating fibers for drug delivery.
  • Drug loading and release are often limited by surface area.
  • Sintering electrospun fibers offers a novel approach for sustained drug release.

Purpose of the Study:

  • To investigate the potential of sintered electrospun polycaprolactone (PCL) fibers as capsules for long-term drug delivery.
  • To evaluate the effect of sintering temperature on PCL fiber morphology, porosity, and drug release kinetics.
  • To correlate PCL capsule properties with the release profiles of model compounds with varying molecular weights.

Main Methods:

  • Electrospinning of polycaprolactone (PCL) fibers.
  • Sintering of PCL fibers at different temperatures (56-59°C).
  • In vitro exposure of PCL fibers and capsules for up to 1042 days.
  • Characterization of fiber morphology and pore size.
  • Drug release studies using Rhodamine B, Rose Bengal, and BSA-FITC as model compounds.
  • COMSOL simulations to model release rates based on capsule properties.

Main Results:

  • Electrospun PCL fibers maintained morphology for over 1000 days.
  • Sintering significantly decreased pore size, with higher temperatures leading to greater reduction.
  • PCL capsules sintered at 58-59°C showed reduced surface porosity but retained entrapped pores.
  • Drug release rates were dependent on molecular weight and available porosity (RhB > RB >> BSA-FITC).
  • Sintered capsules at 58-59°C exhibited sustained release profiles, continuing after 12 days, unlike those sintered at lower temperatures.

Conclusions:

  • Sintering electrospun PCL fibers is a viable method for creating drug-eluting capsules with tunable, long-term release characteristics.
  • Controlled reduction of porosity through sintering modulates drug release kinetics, enabling sustained delivery.
  • The PCL capsules demonstrate potential for extended performance in drug delivery applications, with release profiles influenced by sintering temperature and molecular properties of the released compound.