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Sodium plays a crucial role in maintaining fluid and electrolyte balance and overall bodily homeostasis. Sodium balance is primarily regulated by kidney function, which adjusts sodium elimination to match dietary intake and maintain proper electrolyte levels. Sodium is the most abundant cation in the extracellular fluid (ECF) and is found in salts such as sodium chloride (NaCl) and sodium bicarbonate (NaHCO3). Although cellular plasma membranes are relatively impermeable to sodium, its role in...
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Antiepileptic drugs are specialized medications that prevent seizures in individuals diagnosed with epilepsy. These drugs primarily function by blocking the movement of sodium ions through channels in the neuronal membrane, inhibiting the repetitive firing of action potentials often associated with seizures.
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Quantitation of γH2AX Foci in Tissue Samples
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Quantitating excess tissue sodium.

Gautam Bhave1

  • 1Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, U.S.A. gautam.bhave@vumc.org.

Clinical Science (London, England : 1979)
|March 21, 2019
PubMed
Summary
This summary is machine-generated.

Measuring tissue sodium concentration alone may inaccurately quantify excess sodium, especially in cellular tissues. Combining sodium and water content measurements offers a more accurate assessment of excess tissue sodium.

Area of Science:

  • Biomedical Engineering
  • Physiology
  • Medical Imaging

Background:

  • Sodium MRI (SMRI) measures tissue sodium concentration ([Na+]).
Keywords:
Extracellular MatrixSodiumTonicity

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  • Accurate quantification of tissue sodium is crucial for understanding various physiological and pathological conditions.
  • Cellular tissues present unique challenges for accurate sodium quantification.