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Updated: Jan 27, 2026
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Creation of Two Saccular Elastase-Digested Aneurysms with Different Hemodynamics in One Rabbit
Published on: April 15, 2021
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Hemodynamic Differences Between Recurrent and Nonrecurrent Intracranial Aneurysms: Fluid Dynamics Simulations Based
Michael Hinrich Schönfeld1, Nils Daniel Forkert2, Jens Fiehler1
1Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Summary
Recurrent aneurysms show higher abnormal wall shear stress (WSS) at the neck compared to nonrecurrent ones. Abnormal WSS may predict aneurysm recurrence after treatment.
Area of Science:
- Biomedical Engineering
- Medical Imaging
- Fluid Dynamics
Background:
- Wall shear stress (WSS) is crucial in intracranial aneurysm (IA) development and rupture.
- Its role in IA recurrence post-endovascular treatment needs more study.
Purpose of the Study:
- To compare WSS in recurrent vs. nonrecurrent coil-embolized IAs.
- To assess WSS as a predictor of IA recurrence.
Main Methods:
- Matched nine recurrent and nine nonrecurrent IA cases.
- Used computational fluid dynamics (CFD) on patient-specific geometries from MRA.
- Measured absolute and percentage of abnormal WSS at the aneurysm neck.
Main Results:
- Recurrent IAs had a higher median percentage of abnormal WSS (49.3%) than nonrecurrent ones (34.7%).
- Abnormal WSS percentage distinguished recurrent from nonrecurrent IAs with an AUC of 0.86.
- An optimal cutoff of 45.1% abnormal WSS yielded 88.89% sensitivity and specificity.
Conclusions:
- Recurrent IA necks experience significantly more abnormal WSS.
- Abnormal WSS, identified via CFD, can potentially predict IA recurrence.
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