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Updated: Jan 27, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
Sickle cell disease and readmissions rates after lower extremity arthroplasty: a multistate analysis 2007-2014
Yuefan Chen1, Robert S White2, Virginia Tangel3
1Department of Anesthesiology, Weill Cornell Medicine, 525 East 68th Street, New York, NY 10065, USA.
Aim:
To compare readmission rates between patients with sickle cell disease (SCD) and non-sickle cell disease undergoing total hip and knee arthroplasty (THA and TKA).
Methods:
Identified adult patients who underwent THA or TKA from 2007 to 2014 in California, Florida, New York, Maryland and Kentucky using a multistate database. Outcomes were 30- and 90-day readmission rates, mortality, complications, length of stay and hospital charges. Logistic regression models were used for analysis.
Results:
Compared with non-sickle cell disease patients following TKA and THA, SCD patients had higher odds of 30- (odds ratio [OR]: 3.79) and 90-day readmissions (OR: 4.15), mortality (OR: 6.54), more complications, longer length of stay, and higher total charges.
Conclusion:
Following TKA and THA, SCD is associated with higher readmissions and worse outcomes.
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