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Methodological Approaches to Evaluate Fetal Drug Exposure

Naïm Bouazza1,2,3, Frantz Foissac1,2,3, Déborah Hirt1,2,3,4

  • 1Universite Paris Descartes, EA7323, Sorbonne Paris Cite, France.

Current Pharmaceutical Design
|March 21, 2019
PubMed
Summary

Predicting fetal drug exposure is crucial for maternal-fetal health. Physiologically based pharmacokinetic (PBPK) models show promise for in-silico prediction, but further research on placental development is needed.

Keywords:
Pregnancyfetal drug exposurehuman placental cotyledonpermeabilitypharmacokineticsplacental drug transfer.

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