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Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
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Peroxiporins in Cancer.

Cecilia Prata1, Silvana Hrelia2, Diana Fiorentini3

  • 1Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy. cecilia.prata@unibo.it.

International Journal of Molecular Sciences
|March 22, 2019
PubMed
Summary

Specific aquaporins (AQPs), known as peroxiporins, facilitate hydrogen peroxide (H₂O₂) transport across cell membranes. This review examines their role in cancer and how natural compounds may modulate their activity.

Keywords:
aquaporinscancerhydrogen peroxideperoxiporinsphytochemicalsredox signaling

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Area of Science:

  • Biochemistry
  • Cell Biology
  • Oncology

Background:

  • Hydrogen peroxide (H₂O₂) is a crucial signaling molecule with dual roles as either beneficial or detrimental depending on its concentration and cellular localization.
  • The discovery of specific aquaporins (AQPs) facilitating H₂O₂ transport across membranes, termed 'peroxiporins,' represents a significant advancement in understanding H₂O₂ biochemistry.

Purpose of the Study:

  • To critically review and synthesize current knowledge on AQP isoforms that act as peroxiporins.
  • To investigate the specific involvement of peroxiporins in the development and progression of cancer.
  • To explore the potential of natural compounds in modulating peroxiporin expression and/or activity.

Main Methods:

  • Literature review and critical analysis of existing research on peroxiporins.
  • Focus on studies investigating the role of AQPs in H₂O₂ transport and cellular signaling.
  • Examination of research on the impact of peroxiporins in oncogenic processes.
  • Systematic reporting and discussion of natural compounds affecting peroxiporin function.

Main Results:

  • Identified specific aquaporin (AQP) isoforms functioning as peroxiporins, mediating hydrogen peroxide (H₂O₂) transport.
  • Highlighted the significant role of peroxiporins in various cellular processes, particularly in the context of cancer.
  • Compiled information on natural compounds with the potential to modulate peroxiporin expression and activity.

Conclusions:

  • Peroxiporins are key mediators of H₂O₂ signaling, with implications for cancer biology.
  • Understanding peroxiporin function offers potential therapeutic targets for cancer treatment.
  • Natural compounds represent a promising avenue for developing strategies to modulate peroxiporin activity in cancer therapy.