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Related Concept Videos

What is Gene Expression?01:42

What is Gene Expression?

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Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
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What is Gene Expression?01:36

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A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then...
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A solute is a component of a solution that is typically present at a much lower concentration than the solvent. Solute concentrations are often described with qualitative terms such as dilute (of relatively low concentration) and concentrated (of relatively high concentration).
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Cell Specific Gene Expression01:58

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Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
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Chromatin Position Affects Gene Expression02:35

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Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
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Emotional expression encompasses how individuals convey their emotions through verbal communication and non-verbal cues. These non-verbal actions include facial expressions, body language, and physical gestures, such as frowning or smiling. Among these, facial expressions play a crucial role in emotional expression and are understood universally, indicating a biological basis for how humans communicate emotions.
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webCEMiTool: Co-expression Modular Analysis Made Easy.

Lucas E Cardozo1, Pedro S T Russo1, Bruno Gomes-Correia2

  • 1Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.

Frontiers in Genetics
|March 22, 2019
PubMed
Summary
This summary is machine-generated.

webCEMiTool is a new, automated online tool for gene co-expression analysis. It simplifies complex bioinformatics by identifying gene modules and their functions, making it accessible to researchers without extensive programming skills.

Keywords:
co-expression analysisdata integrationsystems biologytranscriptomicsweb tool

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Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • Co-expression analysis is crucial for understanding gene function in biological processes.
  • Traditional methods require significant programming and bioinformatics expertise, limiting accessibility.

Purpose of the Study:

  • To introduce webCEMiTool, a unique, automated online platform for comprehensive gene co-expression module analysis.
  • To provide researchers with an accessible tool for identifying gene modules, their functions, and network hubs.

Main Methods:

  • Development of a web-based tool, webCEMiTool, for automated co-expression analysis.
  • Integration of transcriptomic data with protein-protein interaction networks.
  • Automated functional enrichment analyses and identification of network hubs.

Main Results:

  • webCEMiTool successfully identifies co-expression gene modules and performs automated functional analyses.
  • The tool integrates transcriptomic and interactome data to pinpoint potential network hubs.
  • User-friendly HTML reports facilitate gene searching and pathway/phenotype association analysis.

Conclusions:

  • webCEMiTool democratizes co-expression analysis by offering a fully automated, user-friendly online solution.
  • The tool aids in elucidating gene functional architecture and identifying key regulatory genes in complex biological systems.
  • Demonstrated utility in analyzing single-cell RNA-seq data from Zika and Dengue virus-infected human cells.