Related Experiment Video

Updated: Jan 27, 2026

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
07:23

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities

Published on: July 29, 2014

34.1K

Studies on a novel regimen for management of orofacial pain and morphine tolerance

Yu-Hsien Lee1,2, Yu-Feng Huang1,2, Hsi-Hsien Chou3,4

  • 1School of Dentistry, College of Oral Medicine, Chung Shan Medical University, Taichung, Taiwan.

Journal of Dental Sciences
|March 22, 2019
PubMed
Abstract

Insights

Green tea polyphenols combined with memantine effectively treat orofacial pain. This novel regimen offers enhanced analgesia and reduced side effects compared to existing treatments.

Area of Science:

  • Pharmacology
  • Neuroscience
  • Pain Management

Background:

  • Orofacial pain has high prevalence but poorly understood etiology.
  • Current treatments for orofacial pain are often ineffective, necessitating novel therapeutic strategies.
  • Developing treatments with improved efficacy and reduced side effects is crucial for clinical application.

Purpose of the Study:

  • To investigate the analgesic effects of green tea polyphenols (GTP) and memantine (Mem) on capsaicin-induced orofacial pain in mice.
  • To evaluate the synergistic effects of GTP and Mem (GTPm) on orofacial pain and morphine's analgesic properties.
  • To assess the impact of GTPm on morphine-induced side effects and tolerance.

Main Methods:

  • Capsaicin injection in mouse vibrissa pad to induce orofacial pain.
  • Oral administration of GTP, Mem, and their combination (GTPm) for 2 weeks.
  • Behavioral analysis using TruScan photobeam tracking to quantify nociception and locomotor activity.
  • Assessment of GTPm effects on morphine analgesia, side effects, and tolerance in both orofacial and thermal pain models.

Main Results:

  • GTPm significantly attenuated capsaicin-induced orofacial pain.
  • GTPm enhanced morphine's analgesic effects and reduced its depressant side effects.
  • The combination therapy delayed the development of morphine tolerance.
  • GTPm and Mem alone reduced morphine analgesia in a hind paw thermal pain model.

Conclusions:

  • Green tea polyphenols (GTP) demonstrate significant analgesic effects on orofacial pain.
  • Memantine combined with GTP (GTPm) exhibits synergistic effects, reducing orofacial pain and enhancing morphine analgesia.
  • The novel regimen of GTPm offers a promising therapeutic strategy for managing orofacial pain with improved outcomes.
Keywords:
N-methyl-d-asparate receptorgreen tea polyphenolmemantineorofacial pain

More Related Videos

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery09:38

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

13.1K
Use of the Operant Orofacial Pain Assessment Device OPAD to Measure Changes in Nociceptive Behavior12:20

Use of the Operant Orofacial Pain Assessment Device OPAD to Measure Changes in Nociceptive Behavior

Published on: June 10, 2013

21.8K

Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
1.6K
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
951
Drug Dosage Regimen: Overview01:15

Drug Dosage Regimen: Overview

A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
4.4K
Dosage Regimen: Individualization01:24

Dosage Regimen: Individualization

Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
178
Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
545
Dosage Regimens: Partial Pharmacokinetic Parameters01:01

Dosage Regimens: Partial Pharmacokinetic Parameters

It is not uncommon for complete drug pharmacokinetic profiles to remain elusive in pharmacokinetics. This necessitates certain educated assumptions by pharmacokineticists to determine appropriate dosage regimens without comprehensive pharmacokinetic data from animal or human studies. One prevalent assumption is setting the bioavailability factor, denoted as F, to 1 or 100%. This assumption caters to the scenario where a drug doesn't achieve full systemic absorption, resulting in the patient...
165