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Association between NAT2 polymorphisms and acute leukemia risk: A meta-analysis.
Xiaoxiao Zhu1, Yanbing Liu2, Guangwu Chen3
1Laboratory for molecular immunology, Institute of Basic Medicine, Shandong Academy of Medical Sciences.
Medicine
|March 22, 2019
Summary
N-acetyl-transferase 2 (NAT2) polymorphisms, specifically rs1801280 and the slow acetylator phenotype, are identified as risk factors for acute leukemia (AL). This meta-analysis clarifies controversial findings regarding NAT2 gene variations and AL susceptibility.
Area of Science:
- Genetics
- Oncology
- Pharmacogenomics
Background:
- N-acetyl-transferase 2 (NAT2) gene polymorphisms are implicated in acute leukemia (AL) development.
- Previous studies on the association between NAT2 variations and AL risk have yielded conflicting results, necessitating further investigation.
Purpose of the Study:
- To conduct a comprehensive meta-analysis to precisely evaluate the association between NAT2 polymorphisms and the risk of acute leukemia.
- To clarify the controversial findings regarding NAT2's role in AL susceptibility.
Main Methods:
- Systematic literature search across major databases including PubMed, Embase, Cochrane Library, CNKI, and Wanfang.
- Meta-analysis using odds ratios (ORs) and 95% confidence intervals (CIs) to quantify the association between NAT2 polymorphisms and AL risk.
- Subgroup analyses were performed based on population ethnicity and genetic models.
Main Results:
- The rs1801280 polymorphism and slow acetylator phenotype were significantly associated with an increased risk of AL under various genetic models.
- Subgroup analysis indicated that rs1801280 is a risk factor for AL in Caucasian and Mixed populations.
- Polymorphisms rs1799929 and rs1799931 showed a decreased risk of AL in Caucasian and Mixed populations, respectively.
Conclusions:
- The rs1801280 polymorphism and slow acetylator phenotype are confirmed as significant risk factors for acute leukemia.
- These findings contribute to a better understanding of the genetic basis of AL and may inform personalized risk assessment.
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