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Updated: Jan 27, 2026

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
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Survivin overexpression in head and neck squamous cell carcinomas as a new therapeutic target (Review)

M A Frassanito1, I Saltarella2, A Vinella1

  • 1Department of Biomedical Sciences and Human Oncology, Unit of General Pathology, University of Bari Aldo Moro, I‑70124 Bari, Italy.

Oncology Reports
|March 22, 2019
PubMed

Insights

Survivin, a protein overexpressed in head and neck squamous cell carcinoma (HNSCC), plays a key role in regulating apoptosis and autophagy. Targeting survivin presents a potential new therapeutic strategy for HNSCC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Head and neck squamous cell carcinoma (HNSCC) is a globally prevalent cancer with poor prognosis.
  • Chemotherapy resistance in HNSCC is linked to dysregulation of apoptosis and autophagy.
  • Survivin, an inhibitor of apoptosis protein (IAP), is overexpressed in HNSCC and serves as a tumor biomarker.

Purpose of the Study:

  • To review the expression and function of survivin in tumor progression.
  • To elucidate survivin's role in regulating apoptosis and autophagy in HNSCC.
  • To explore survivin targeting as a potential therapeutic strategy for HNSCC.

Main Methods:

  • Literature review of studies on survivin expression and function.
  • Analysis of survivin's involvement in apoptosis and autophagy pathways.
  • Evaluation of survivin as a therapeutic target based on existing data.

Main Results:

  • Survivin is selectively overexpressed in HNSCC tumors compared to normal tissues.
  • Survivin is a critical regulator of both apoptosis and autophagy.
  • Its overexpression contributes to chemoresistance and disease progression in HNSCC.

Conclusions:

  • Survivin's nodal role in regulating apoptosis and autophagy makes it a significant factor in HNSCC progression.
  • Targeting survivin offers a promising novel therapeutic avenue for managing HNSCC.

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