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PD-1 Ligand Expression in Epithelial Thyroid Cancers: Potential Clinical Implications

Salvatore Ulisse1, Chiara Tuccilli2, Salvatore Sorrenti3

  • 1Department of Surgical Sciences, "Sapienza" University of Rome, 00161 Rome, Italy. salvatore.ulisse@uniroma1.it.

International Journal of Molecular Sciences
|March 23, 2019
PubMed

Insights

New immunotherapies targeting programmed cell death 1 (PD-1) and PD-L1 offer hope for treating difficult thyroid cancers. Research explores PD-L1 expression and the PD-1/PD-L1 axis as a potential therapeutic target for these unresponsive cancers.

Area of Science:

  • Oncology
  • Immunology
  • Cancer Research

Background:

  • Thyroid cancers, particularly poorly differentiated and anaplastic types, are often resistant to current treatments.
  • Immunotherapy targeting the programmed cell death 1 (PD-1) receptor and its ligand PD-L1 shows promise in treating various cancers.

Purpose of the Study:

  • To review the expression of PD-L1 in different thyroid cancer histotypes.
  • To correlate PD-L1 expression with clinicopathological features and assess its prognostic value.
  • To evaluate the PD-1/PD-L1 axis as a potential therapeutic target for thyroid cancer.

Main Methods:

  • Literature review of studies on PD-L1 expression in thyroid cancer.
  • Analysis of correlations between PD-L1 expression and clinicopathological parameters.
  • Evaluation of preclinical and clinical data on PD-1/PD-L1 blockade in thyroid cancer.

Main Results:

  • PD-L1 is expressed in various thyroid cancer histotypes, with varying frequencies.
  • PD-L1 expression may correlate with specific clinicopathological features and potentially influence prognosis.
  • Emerging data suggest the PD-1/PD-L1 pathway is a viable target for thyroid cancer immunotherapy.

Conclusions:

  • Understanding PD-L1 expression in thyroid cancer is crucial for identifying potential responders to immunotherapy.
  • The PD-1/PD-L1 axis represents a promising therapeutic avenue for refractory thyroid cancers.
  • Further research is warranted to optimize PD-1/PD-L1 targeted therapies for thyroid cancer patients.
Keywords:
diagnosisprognosisprogrammed cell death 1programmed cell death ligand 1therapythyroid cancer

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