Related Experiment Video
Updated: Jan 27, 2026

Quantifying the Antifungal Activity of Peptides Against Candida albicans
Published on: January 13, 2023
Local delivery polymer provides sustained antifungal activity of amphotericin B with reduced cytotoxicity
Rebecca M Haley1, Sean T Zuckerman2, Catherine A Gormley1
11 Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
Impact Statement:
Amphotericin B (AmB) is an effective and commonly used antifungal agent. However, nephrotoxicity and poor solubility limits its usage. The proposed polymerized cyclodextrin (pCD) system therefore is an attractive method for AmB delivery, as it retains the antifungal activity of AmB while decreasing toxicity, and confining drug release to the local environment. This system could potentially be used for both prevention and treatment of established fungal infections, as AmB is toxic to fungus whether associated or released from pCD.
Related Concept Videos
Sustainable Development
Polymers
Polymers
Local Anesthetics: Chemistry and Structure-Activity Relationship
Design Example: Sustainability in Concrete Building
There are multiple approaches to achieve sustainability in a commercial concrete building. For instance, construct a concrete parking area under the building, utilizing pervious concrete paver blocks in open areas to facilitate rainwater collection through an underground...
Reducing Line Loss
With a step-up transformer at the source, the voltage is increased, thereby reducing the current in the transmission lines since power loss in...

