Free flaps for lower limb soft tissue reconstruction in children: Systematic review
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Updated: Jan 27, 2026

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Published on: December 5, 2025
Karel Ey Claes1, Nathalie A Roche1, Dries Opsomer1
1Department of Plastic Surgery, Ghent University Hospital, C. Heymanslaan 10, 9000 Gent, Belgium.
Insights
The anterolateral thigh (ALT) flap is the preferred method for pediatric lower limb soft tissue reconstruction due to its low complication rate. Other free flaps like the radial forearm (RFA) flap also show promising results.
Area of Science:
- Pediatric Microsurgery
- Reconstructive Surgery
- Limb Reconstruction
Background:
- Microsurgery techniques have advanced, leading to a preference for free flaps in pediatric soft tissue defect reconstruction.
- This evolution reflects a move towards more sophisticated reconstructive options in pediatric care.
Purpose of the Study:
- To systematically compare complication rates between free perforator/fasciocutaneous flaps and free muscular/myocutaneous flaps for pediatric lower limb soft tissue defects.
- To assess the frequency and severity of complications associated with each reconstructive approach.
Main Methods:
- A systematic review was conducted using major scientific databases (PubMed, Web of Science, Embase, Scopus, Cochrane Library).
- Inclusion criteria were predefined to ensure a focused analysis of relevant studies.
Main Results:
- The anterolateral thigh (ALT) flap emerged as the most frequent and successful option, with an 11.3% complication rate and minimal flap loss.
- The latissimus dorsi (LD) flap and thoracodorsal artery perforator (TDAP) flap had comparable complication rates (32% vs. 39%), with LD flaps experiencing fewer failures.
- The radial forearm (RFA) fasciocutaneous flap is a viable alternative, demonstrating a low complication rate (16%) and no flap loss.
Conclusions:
- The ALT flap is identified as the optimal reconstructive method for pediatric lower limb soft tissue defects.
- Further prospective research is needed to establish definitive guidelines for free flap reconstruction in pediatric lower limb defects and optimize long-term outcomes.
Background:
Since the first reports on microsurgery in children, there has been an evolution in the reconstruction of soft tissue defects as evidenced by a shift to free flaps as the first-line treatment.
Methods:
The primary objective of this systematic review was to compare the complication rate of free perforator/fasciocutaneous flaps with free muscular/myocutaneous flaps in pediatric lower limb soft tissue reconstructions. The secondary objective was to evaluate the frequency and severity of complications for both reconstructive options. A search was performed in the databases PubMed, Web of Science, Embase, Scopus, and Cochrane Library depending on predefined inclusion criteria.
Results:
The evolution to perforator flaps from muscular and myocutaneous flaps is reflected in this systematic review as demonstrated by the anterolateral thigh (ALT) flap, which is the most common reconstructive option with a very low complication rate (11.3%) and flap loss. The latissimus dorsi (LD) flap was the second most frequently reported reconstruction with a complication rate comparable with that of the thoracodorsal artery perforator (TDAP) flap (32% vs. 39%, respectively), but the former suffers few failures. The radial forearm (RFA) fasciocutaneous flap can be considered a good alternative for ALT and TDAP flaps with a very low complication rate (16%) and no flap loss.
Conclusions:
The ALT flap is considered the best reconstructive method for pediatric lower limb soft tissue defects. More adequate prospective studies specifically concerning free flap reconstructions for lower limb defects in children are necessary in the future to provide guidelines for treatment and optimize outcomes in the long term.
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