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Updated: Jan 27, 2026

Multiscale Structures Aggregated by Imprinted Nanofibers for Functional Surfaces
Published on: September 11, 2018
Multiscale recordings reveal the dynamic spatial structure of human seizures
Catherine A Schevon1, Steven Tobochnik1, Tahra Eissa2
1Department of Neurology, Columbia University Medical Center, New York, NY, USA.
Abstract:
The cellular activity underlying human focal seizures, and its relationship to key signatures in the EEG recordings used for therapeutic purposes, has not been well characterized despite many years of investigation both in laboratory and clinical settings. The increasing use of microelectrodes in epilepsy surgery patients has made it possible to apply principles derived from laboratory research to the problem of mapping the spatiotemporal structure of human focal seizures, and characterizing the corresponding EEG signatures. In this review, we describe results from human microelectrode studies, discuss some data interpretation pitfalls, and explain the current understanding of the key mechanisms of ictogenesis and seizure spread.
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