Hemospray hemostasis in bleeding diffusely ulcerated esophagus.

Area of Science:

• Gastroenterology
• Endoscopy
• Hemostasis

Background:

• Diffuse esophageal ulcerations present a significant challenge for hemostasis.
• Conventional treatments like clipping and injection therapy may be insufficient for severe bleeding.
• Hemospray, a hemostatic powder, acts by concentrating clotting factors and forming mechanical plugs.

Purpose of the Study:

• To evaluate the efficacy of Hemospray as a first-line monotherapy for diffuse esophageal ulcerations with significant bleeding.
• To assess the potential of Hemospray in reducing the need for repeat endoscopic procedures.
• To explore the cytoprotective role of Hemospray in promoting ulcer healing.

Main Methods:

• Case series of 3 patients with diffusely ulcerated esophagus and significant bleeding.
• Initial 2 cases refractory to conventional hemostatic treatments (clipping, injection therapy).
• Hemospray utilized as first-line monotherapy in the third case.

Main Results:

• Immediate hemostasis achieved in all 3 patients.
• No recurrent bleeding observed in any patient for over 2 months post-treatment.
• Hemospray demonstrated successful control of diffuse esophageal bleeding.

Conclusions:

• Hemospray application is proposed as a first-line therapy for diffuse esophageal ulcerations with significant bleeding.
• This approach may decrease the requirement for repeat endoscopic interventions.
• Hemospray forms a protective barrier, facilitating mucosal healing by shielding from acid reflux.