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Published on: April 22, 2016
Formylation of Fluoroalkyl Imines through Visible-Light-Enabled H-Atom Transfer Catalysis: Access to Fluorinated
Sen Yang1, Shuangyu Zhu1, Dengfu Lu1
1School of Chemistry and Chemical Engineering , Huazhong University of Science and Technology , 1037 Luoyu Rd. , Wuhan , Hubei 430074 , China.
Abstract:
A visible-light-enabled catalytic formylation of fluoroalkyl imines is developed. With readily accessible starting materials and organocatalysts, this method provides a general approach to masked fluoroalkyl amino aldehydes. A synergistic catalytic effect between the photosensitizer and the H atom transfer agent was proven pivotal to this transformation. After removing the mask, free aldehydes can be obtained and further converted to various β-fluoroalkyl β-amino alcohols, which are attractive building blocks in the synthesis of bioactive and pharmaceutical compounds.
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