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N-terminal probrain natriuretic peptide as biomarker for diagnosis of Kawasaki disease

Moises Rodriguez-Gonzalez1, Alvaro A Perez-Reviriego2, Ana Castellano-Martinez3

  • 1Department of Pediatric Cardiology, Puerta del Mar University Hospital, Cadiz 11011 Spain.

Biomarkers in Medicine
|March 23, 2019
PubMed

Insights

Early recognition of Kawasaki disease (KD) is crucial. N-terminal probrain natriuretic peptide shows promise as a biomarker to improve the diagnosis of this childhood vasculitis, aiding timely treatment.

Area of Science:

  • Pediatrics
  • Cardiology
  • Immunology

Background:

  • Kawasaki disease (KD) is a critical childhood vasculitis affecting the heart.
  • Coronary artery aneurysms are a major cause of mortality in KD patients.
  • Early diagnosis and treatment with gammaglobulin reduce aneurysm risk.

Purpose of the Study:

  • To review the diagnostic utility of N-terminal probrain natriuretic peptide (NT-proBNP) in Kawasaki disease.
  • To assess NT-proBNP as a biomarker for enhancing KD diagnosis.

Main Methods:

  • Literature review of recent studies on NT-proBNP in KD diagnosis.
  • Analysis of diagnostic accuracy of NT-proBNP in suspected KD cases.

Main Results:

  • NT-proBNP demonstrates significant potential as a biomarker for KD.
  • Incorporating NT-proBNP can improve the accuracy of current diagnostic methods for KD.

Conclusions:

  • NT-proBNP is a valuable addition to the diagnostic workup for suspected Kawasaki disease.
  • This biomarker can increase diagnostic accuracy, facilitating earlier intervention for KD.

Keywords:
Kawasaki diseaseNT-proBNPbiomarkerschildrencoronary artery aneurysmechocardiographyinflammationmyocardial ischemianatriuretic peptidesprolonged fever

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