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Updated: Jan 27, 2026
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Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
Published on: April 11, 2018
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Primary orbital low-grade fibromyxoid sarcoma - A case report
Raksha Rao1, Santosh G Honavar1, Kaustubh Mulay2
1Department of Ocular Oncology, Centre for Sight, Asoka Capitol Building, Road No 2, Banjara Hills, Hyderabad, Telangana, India.
Indian Journal of Ophthalmology
|March 23, 2019
Summary
This is the first reported case of orbital low-grade fibromyxoid sarcoma (LGFS) in an 18-year-old female. The rare orbital tumor was successfully treated with stereotactic radiotherapy.
Area of Science:
- Ophthalmology
- Oncology
- Pathology
Background:
- Low-grade fibromyxoid sarcoma (LGFS) is a rare soft tissue tumor typically affecting adults.
- Orbital tumors can present with varied symptoms, including proptosis and visual disturbances.
Observation:
- An 18-year-old female presented with one month of rapidly progressive left eye proptosis and a relative afferent pupillary defect.
- Orbital imaging revealed an extraconal mass near the lateral rectus muscle, extending to the superior orbital fissure with associated bony erosion.
Findings:
- Histopathology confirmed the mass as composed of stellate to spindle-shaped fibroblasts in a myxoid matrix, consistent with LGFS.
- This represents the first documented case of LGFS occurring in the orbit.
Implications:
- This case expands the known anatomical sites for LGFS.
- Stereotactic radiotherapy is a viable treatment option for orbital LGFS.
- Highlights the importance of considering rare diagnoses in orbital masses presenting with aggressive features.
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