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Related Concept Videos

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Related Experiment Video

Updated: Jan 27, 2026

Designing a Bio-responsive Robot from DNA Origami
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Delivering DNA origami to cells.

Dhanasekaran Balakrishnan1,2, Gerrit D Wilkens1,2, Jonathan G Heddle1

  • 1Bionanoscience & Biochemistry Laboratory, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7A, 30-387 Krakow, Poland.

Nanomedicine (London, England)
|March 23, 2019
PubMed
Summary

DNA origami offers functional molecule delivery potential but faces challenges. This review details progress in overcoming hurdles like stability, cell targeting, and endosomal escape for intracellular delivery.

Keywords:
DNA nanotechnologyDNA origamicell deliverycell targetingnanorobotssmart medicines

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Area of Science:

  • Biotechnology
  • Nanotechnology
  • Molecular Biology

Background:

  • DNA nanotechnology shows promise for creating functional molecules for cellular delivery.
  • DNA origami, a subset of DNA nanotechnology, is emerging as a viable tool for this purpose.
  • Despite advances, significant challenges impede the clinical application of DNA origami structures.

Purpose of the Study:

  • To review the progress made in addressing the hurdles of DNA origami for cellular delivery.
  • To discuss the remaining challenges in the field.
  • To explore the potential functionality of DNA origami structures within cells.

Main Methods:

  • Literature review of recent advances in DNA origami for biomedical applications.
  • Analysis of challenges including stability, cell targeting, and intracellular trafficking.
  • Discussion of strategies for endosomal escape and subcellular localization.

Main Results:

  • Progress has been made in enhancing the stability of DNA origami structures for in vivo administration.
  • Various methods for cell targeting and improving cellular uptake are being developed.
  • Strategies to facilitate endosomal escape and achieve specific subcellular localization are under investigation.

Conclusions:

  • DNA origami is a rapidly advancing field with significant potential for targeted intracellular delivery.
  • Overcoming challenges in stability, targeting, uptake, and intracellular trafficking is crucial for clinical translation.
  • Future research will focus on optimizing DNA origami for specific intracellular functions and therapeutic applications.