Related Experiment Video
Updated: Jan 27, 2026

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
Predictive importance of galectin-3 for recurrence of non-small cell lung cancer
Yoko Kataoka1,2, Tomoyuki Igarashi3, Yasuhiko Ohshio3
1Department of Surgery, Shiga University of Medical Science, Seta- Tsukinowa, Otsu, Shiga, 520-2192, Japan. ykataoka@belle.shiga-med.ac.jp.
Objective:
The predictive importance of galectin-3 in non-small cell lung cancer (NSCLC) has not been elucidated. We examined whether galectin-3 could serve as a predictor for tumor recurrence in NSCLC.
Methods:
In 42 consecutive patients with NSCLC who underwent radical resection, galectin-3 expression in tumor cells was examined by immunohistochemistry. Galectin-3 levels in serum were assessed before surgery and 1 month after surgery by enzyme-linked immunosorbent assays.
Results:
Higher expression of galectin-3 in tumor cells was associated significantly with lymphatic invasion (p = 0.049) and tumor recurrence (p = 0.001). The Kaplan-Meier curves for relapse-free survival after radical resection showed that patients with high expression of galectin-3 had significantly shorter relapse-free survival than those with low expression of galectin-3 (p < 0.001). The serum level of galectin-3 was not reduced after radical resection, and there was no significant correlation between the serum level of galectin-3 and recurrence.
Conclusions:
Galectin-3 expression in tumor cells could serve as a predictive factor for recurrence, but serum level of galectin-3 is not useful for predicting NSCLC recurrence.
Related Concept Videos
Predicting Molecular Geometry
Lung Capacity
Prediction Intervals
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y.
End Point Prediction: Gran Plot
For potentiometric titration, the Gran plot is created by plotting...
Sensitivity, Specificity, and Predicted Value
Sensitivity is the...
Predicting Reaction Outcomes

