Dutch multicenter experience using the STENTYS Xposition S self-apposing stent in complex coronary lesions

Area of Science:

• Interventional Cardiology
• Cardiovascular Devices
• Clinical Practice Research

Background:

• Complex coronary lesions present challenges in stent sizing and can lead to complications like overdilation or underexpansion.
• The Xposition S stent's self-apposing feature aids in achieving good strut apposition, particularly in complex vessel anatomies.
• This stent design allows for post-implantation diameter adjustment, addressing some limitations of traditional stents.

Purpose of the Study:

• To evaluate the clinical experience and outcomes of using the Xposition S self-apposing stent in the Netherlands.
• To assess the stent's performance in treating complex coronary lesions within a real-world clinical setting.
• To determine the 1-year rate of major adverse cardiac events (MACE) associated with the Xposition S stent.

Main Methods:

• A prospective, real-world registry was conducted across four Dutch clinical sites.
• Data were collected from patients treated with the Xposition S stent, adhering to current implantation recommendations.
• The primary endpoint evaluated was the incidence of major adverse cardiac events (MACE) at one year post-implantation.

Main Results:

• The study included 251 patients treated between 2015 and 2018, with a majority presenting with acute coronary syndrome (76.9%).
• Common indications included aneurysmatic/ectatic vessels (32.3%) and thrombus-containing lesions (13.1%), with most lesions classified as AHA/ACC Type C (53.6%).
• Successful device implantation was achieved in 96.8% of target lesions, with a 1-year MACE rate of 6.6% and a low stent thrombosis rate of 1.0%.

Conclusions:

• The STENTYS Xposition S stent demonstrated favorable procedural outcomes in Dutch clinical practice.
• The stent achieved a low 1-year clinical event rate, including MACE and stent thrombosis.
• These findings support the use of the Xposition S self-apposing stent in complex coronary anatomies.