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Soluble Vascular Cell Adhesion Molecule-1 Is Associated With Disease Activity in Adult-Onset Minimal Change Disease

Qingyan Zhang1, Miao Zhang1, Cheng Sun1

  • 1Department of Nephrology, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.

The American Journal of the Medical Sciences
|March 25, 2019
PubMed
Abstract

Insights

Soluble vascular cell adhesion molecule-1 (sVCAM-1) and E-selectin (sE-selectin) are elevated in active Minimal Change Disease (MCD). sVCAM-1 levels correlate with disease activity, indicating its potential as a biomarker for MCD.

Area of Science:

  • Immunology
  • Nephrology
  • Biomarker Discovery

Background:

  • Immune inflammatory diseases are often associated with elevated cell adhesion molecules.
  • Minimal Change Disease (MCD) is an immune disorder characterized by nephrotic-range proteinuria.
  • The role of soluble adhesion molecules in MCD activity requires further investigation.

Purpose of the Study:

  • To investigate the association between soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble E-selectin (sE-selectin) levels and disease activity in adult-onset Minimal Change Disease (MCD).
  • To determine if these soluble adhesion molecules can serve as biomarkers for MCD activity.

Main Methods:

  • A sandwich enzyme-linked immunosorbent assay (ELISA) was employed to quantify sVCAM-1 and sE-selectin.
  • Levels were measured in 40 adult patients with biopsy-proven MCD at diagnosis and during remission.
  • A control group of 35 healthy volunteers was included for comparison.

Main Results:

  • Patients with active MCD exhibited significantly higher levels of sVCAM-1 and sE-selectin compared to healthy controls.
  • sVCAM-1 showed significant positive correlations with urine protein and serum cholesterol, and a negative correlation with serum albumin.
  • Serum albumin was identified as an independent predictor of sVCAM-1 levels. sE-selectin did not show significant correlations with clinical parameters.
  • These markers decreased during disease remission, though elevated sVCAM-1 persisted in some patients even after 6 months of complete remission.

Conclusions:

  • Elevated levels of sVCAM-1 and sE-selectin are observed in patients with active MCD.
  • The strong correlation between sVCAM-1 and clinical indicators of disease activity (proteinuria, serum albumin, cholesterol), along with its decline during remission, suggests its utility as a biomarker for MCD.
  • sVCAM-1 may serve as a valuable indicator of disease activity and response to treatment in Minimal Change Disease.
Keywords:
Disease activityMinimal change diseaseSoluble adhesion molecules

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