Related Experiment Video
Updated: Jan 27, 2026
Murine Model of Intestinal Ischemia-reperfusion Injury
Published on: May 11, 2016
Ischemia-Reperfusion Injury in Sickle Cell Disease: From Basics to Therapeutics
Junaid Ansari1, Felicity N E Gavins1
1Department of Molecular & Cellular Physiology, Louisiana State University Health Sciences Center Shreveport, Shreveport, Louisiana.
Insights
Sickle cell disease (SCD) causes chronic anemia and vascular issues, leading to repeated ischemia-reperfusion injury (I/RI). Understanding I/RI mechanisms is key to developing new therapies for SCD complications.
Area of Science:
- Hematology
- Vascular Biology
- Pathophysiology
Background:
- Sickle cell disease (SCD) is a prevalent global hemoglobinopathy affecting nearly 400,000 newborns annually.
- SCD is characterized by chronic hemolytic anemia and endothelial dysfunction, causing vascular disruption and recurrent ischemia-reperfusion injury (I/RI).
- I/RI is a critical vascular process implicated in various conditions, including myocardial infarction, stroke, and acute kidney injury.
Purpose of the Study:
- To review the evolving pathobiology of sickle cell disease.
- To elucidate how SCD complications are linked to ischemia-reperfusion injury (I/RI).
- To discuss the potential of therapeutic interventions targeting I/R insult mediators in SCD.
Main Methods:
- Literature review focusing on recent advances in SCD pathophysiology.
- Analysis of the relationship between SCD mechanisms and I/RI.
- Synthesis of information on therapeutic targets for I/R injury in SCD.
Main Results:
- SCD pathophysiology involves chronic vascular disruption and endothelial dysfunction.
- Recurrent ischemia-reperfusion injury (I/RI) is a central mechanism underlying SCD complications.
- Targeting I/R pathways presents a promising therapeutic strategy for managing SCD.
Conclusions:
- The understanding of SCD is increasingly linked to ischemia-reperfusion injury (I/RI) mechanisms.
- Therapeutic strategies aimed at mitigating I/R insult are crucial for addressing SCD morbidity.
- Further research into I/RI mediators can lead to novel treatments for sickle cell disease.
Abstract:
Sickle cell disease (SCD) is one of the most common hereditary hemoglobinopathies worldwide, affecting almost 400,000 newborns globally each year. It is characterized by chronic hemolytic anemia and endothelial dysfunction, resulting in a constant state of disruption of the vascular system and leading to recurrent episodes of ischemia-reperfusion injury (I/RI) to multiple organ systems. I/RI is a fundamental vascular pathobiological paradigm and contributes to morbidity and mortality in a wide range of conditions, including myocardial infarction, stroke, acute kidney injury, and transplantation. I/RI is characterized by an initial restriction of blood supply to an organ, which can lead to ischemia, followed by the subsequent restoration of perfusion and concomitant reoxygenation. Recent advances in the pathophysiology of SCD have led to an understanding that many of the consequences of this disease can be explained by mechanisms associated with I/RI. The following review focuses on the evolving pathobiology of SCD, how various complications of SCD can be attributed to I/RI, and the role of timely therapeutic intervention(s) based on targeting mediators or pathways that influence I/R insult.
Related Concept Videos
02:27Energy Basics
01:22Pathophysiology of Peptic Ulcer Disease: Injurious Factors
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
01:22Basic Operations on Signals
Time Reversal mirrors a continuous-time signal about the vertical axis at t=0. This is achieved by substituting t with −t. For example, if a signal x(t) is considered, the time-reversed signal is x(−t). This operation can be graphically represented, showing the mirrored signal.
01:21Basicity of Aliphatic Amines
To measure the basicity of amines, two conventions are generally used. The first defines Kb as the basicity constant for the deprotonation reaction of water by the amine, as presented in Figure 1. Conventionally, lower Kb indicates higher...
02:52VSEPR Theory and the Basic Shapes
01:28Basic Concept
Length, which measures the distance traveled by an object, is a fundamental concept in engineering mechanics. We use coordinates relative to a reference point to describe the distance. Length not only helps to describe the...