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Related Experiment Video

Updated: Jan 27, 2026

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
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Indexing left ventricular wall thickness to body surface area improves prognostic value.

Troy M LaBounty1, David S Bach1, Eduardo Bossone2

  • 1Department of Medicine, University of Michigan, Ann Arbor, Michigan.

Echocardiography (Mount Kisco, N.Y.)
|March 25, 2019
PubMed
Summary

Indexing left ventricular (LV) wall thickness (WT) to body surface area (BSA) significantly improves mortality prediction compared to non-indexed measurements. This method offers superior prognostic value in patients undergoing echocardiography.

Keywords:
echocardiographyleft ventricular hypertrophyoutcomes

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Area of Science:

  • Cardiology
  • Medical Imaging
  • Prognostics

Background:

  • Current guidelines for normal left ventricular (LV) wall thickness (WT) do not utilize indexing to body surface area (BSA).
  • The prognostic value of indexed WT for mortality risk remains underexplored in clinical practice.

Purpose of the Study:

  • To investigate the hypothesis that indexing LV wall thickness (WT) to body surface area (BSA) enhances its prognostic capability.
  • To compare the predictive accuracy of indexed WT against non-indexed WT and LV mass index (LVMI) for mortality risk.

Main Methods:

  • A retrospective analysis of 9737 patients who underwent echocardiography was performed.
  • The relationship between LV wall thickness (WT) and body surface area (BSA) was examined.
  • The association of WT, LV mass index (LVMI), and indexed WT with mortality was assessed, adjusting for age and gender.

Main Results:

  • A significant linear relationship was observed between body surface area (BSA) and left ventricular (LV) wall thickness (WT).
  • Indexed mean WT (MWT) demonstrated the highest prognostic value for mortality prediction (C-statistic 0.67) compared to non-indexed MWT and LVMI.
  • Patients with indexed MWT in the 8th decile or higher showed significantly increased adjusted mortality risk.

Conclusions:

  • Indexing left ventricular wall thickness (WT) to body surface area (BSA) provides improved mortality prediction over non-indexed WT and LVMI.
  • The findings support the routine use of indexed WT for enhanced risk stratification in echocardiographic assessments.