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Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice
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Cocaine-associated decision-making: Toward isolating preference.

Joshua S Beckmann1, Jonathan J Chow1, Blake A Hutsell2

  • 1Department of Psychology, University of Kentucky, 741 S. Limestone, Lexington, KY, 40536, USA.

Neuropharmacology
|March 26, 2019
PubMed
Summary
This summary is machine-generated.

This study developed a new method to measure cocaine preference, showing that drug intake and preference are separate. This finding advances understanding of decision-making in substance use disorders.

Keywords:
ChoiceCocaineDecision-makingEconomic substitution

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Area of Science:

  • Neuroscience
  • Behavioral Economics
  • Addiction Research

Background:

  • Substance use disorder (SUD) is linked to decision-making processes.
  • Non-drug alternatives may shift preferences away from drugs like cocaine.
  • Conflicting theories exist on whether cocaine preference is a byproduct of intake or determined by reinforcer dimensions.

Purpose of the Study:

  • To develop a novel drug-choice procedure to disentangle cocaine intake from preference.
  • To test quantitative choice theories by controlling for reinforcer frequency and magnitude.
  • To investigate the neurobehavioral underpinnings of decision-making in substance use disorders.

Main Methods:

  • Developed a novel drug-choice procedure controlling for reinforcer frequency and magnitude.
  • Controlled for overall cocaine intake while measuring choice behavior.
  • Administered various manipulations known to alter cocaine reinforcement.

Main Results:

  • Cocaine intake and preference were found to be dissociable, supporting quantitative choice theory.
  • Reinforcer frequency and magnitude independently influenced the relative value of choice alternatives.
  • The developed choice procedure was sensitive to manipulations altering cocaine reinforcement, with constant intake.

Conclusions:

  • The study demonstrates that cocaine preference is not solely a byproduct of intake.
  • Economic substitution is a key process for future research in SUD therapies.
  • The novel choice procedure allows for better isolation of neurobehavioral processes in drug-associated decision-making.