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KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer

Wenting Liao1, Michael J Overman2, Adam T Boutin3

  • 1Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China; Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Guangzhou, Guangdong, China.

Cancer Cell
|March 26, 2019
PubMed

Keywords:
CXCL3CXCR2IRF2KRASanti-PD-1colorectal cancer (CRC)immune checkpoint blockade (ICB)

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